Bioavailability of a New Oral Spray Melatonin Emulsion Compared with a Standard Oral Formulation in Healthy Volunteers

In recent years, sleep disturbances have been documented to affect up to thirty percent of the Western hemisphere’s population. Depression, anxiety and stress are the most common causes of sleep disturbances related to sleep-onset and sleep-maintenance difficulties. Sleep disturbances are common in the elderly, apart from psychological causes; they may be caused by side effects of medication or disease [1].